Hal Robson-Kanu is the latest withdrawal from Wales’ squad for the World Cup qualifier against Serbia in Belgrade on Sunday.
The West Bromwich Albion striker’s place is taken by 17-year-old Swansea City winger Daniel James.
Liverpool forward Ben Woodburn earlier pulled out of the trip because of a calf injury.
Woodburn, 17, was replaced in the 23-man squad by another uncapped player, Marley Watkins.
Watkins, who has agreed a move to Norwich City from Barnsley, had been part of Wales’ recent training camp in Portugal.
Serbia are top of Group D, four points ahead of third-placed Wales with five games remaining.
Forward Gareth Bale and defender Neil Taylor are suspended for the game against Serbia, while defender James Collins and midfielders Andy King and Jonny Williams are injured.
Wales squad to face Serbia
Goalkeepers: Wayne Hennessey (Crystal Palace), Danny Ward (Liverpool), Owain Fon Williams (Inverness Caledonian Thistle)
Defenders: Ashley Williams (Everton), Chris Gunter (Reading), James Chester (Aston Villa), Ben Davies (Tottenham Hotspur), Jazz Richards (Cardiff City), Joe Walsh (MK Dons), Tom Lockyer (Bristol Rovers), Gethin Jones (Everton)
Midfielders: Aaron Ramsey (Arsenal), Joe Ledley (Crystal Palace), Emyr Huws (Cardiff City), Dave Edwards (Wolverhampton Wanderers), Joe Allen (Stoke City), Lee Evans (Wolverhampton Wanderers), Harry Wilson (Liverpool)
Forwards: Tom Lawrence (Leicester City), Daniel James (Swansea City), Sam Vokes (Burnley), Tom Bradshaw (Barnsley), Marley Watkins (Norwich City)
SOURCE BY BBC….